Sunderland and Middlesbrough have already been sentenced to Championship football next season so only one more side will suffer the despair of relegation.
While Hull, Swansea and Crystal Palace are all in real danger of the drop, Burnley and Watford are all but mathematically safe.
The Hornets have a difficult run in with Everton (A), Chelsea (A) and Man City (H) in their final three, while Burnley face Bournemouth (A) and West Ham (H). It would be a real shock if either went down on 40 points.
This weekend includes arguably the biggest match of both Crystal Palace and Hull's seasons. They go head-to-head at Selhurst Park on Sunday (12:00) and a home win, combined with a Swansea win on the Saturday, would mean Hull have no way of escaping the drop.
But as we have all come to know and love about football, there are always twists and turns in a relegation dog-fight. Here, we take a look at three players who could become heroes and rack you up those all-important TFF points.
Christian Benteke (£5.2m)
Only two strikers have chalked up more TFF points in the last six weeks than Christian Benteke (Sergio Aguero and Son Heung-Min). He's scored three times since Week 36 and has been instrumental in the Eagles' fight for survival. Sam Allardyce has never managed a side that has suffered relegation and it wouldn't be a surprise if that trend continued this season too.
16th (38 points)
Hull City (H)
Manchester United (A)
Harry Maguire (£2.2m)
The man entrusted with keeping Benteke quiet on Sunday will be Hull's Harry Maguire. The Tigers would probably be relegated already if it wasn't for his performances in recent weeks - he scored in both Week 36 and 37 and impressed during Hull's run of four wins in seven games (Weeks 31-37).
What's more, he's helped install a bit of confidence at the back as Hull have kept two clean sheets in their last three outings. To keep their fate in their own hands, Maguire will have to inspire Hull to a win. Following that, they have a home clash against Spurs who should already have secured second place. Game on.
18th (34 points)
Crystal Palace (A)
Gylfi Sigurdsson (£4.6m)
No shocks here. When you think of the Swans, thoughts immediately turn to Sigurdsson. The Icelandic midfielder has scored nine goals and produced 15 key contributions this season - a fantastic return considering their current league position.
The good news for the Welsh side is that they have the easier run in. They travel to already-relegated Sunderland on Saturday then, if required, have a final-day home clash with West Brom.
Now is the time to take a punt on Sigurdsson if you're in need of some last minute TFF points.
17th (35 points)
West Brom (H)